cordis coronary stent

), Press Contacts:Sandy Poundspound@its.jnj.com(908) 432-2829 cell(908) 541-4040 office, Investor Contacts:Louise Mehrotra(732) 524-6491Stan Panasewicz(732) 524-2524, Pharmaceutical Companies of Johnson & Johnson, Reimagining the Way Healthcare Is Delivered, Advancing New Healthcare Solutions Through Collaboration, Learn About the Company's Rich Heritage at Our Digital Museum. Vascular response to bioresorbable polymer sirolimus-eluting stent versus permanent polymer everolimus-eluting stent at 9-month follow-up: an optical coherence tomography sub-study from the CENTURY II trial. As the leader in EP navigation systems and ablation therapy, Biosense Webster, Inc. has technology that includes the largest installed base of cardiac mapping navigation systems worldwide in leading hospitals and teaching institutions. In fact, the CYPHER(R) stent has shown more than 70% risk reduction in target lesion revascularization (TLR) when compared with bare metal stents. Joner, M. et al. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Circulation 133, 650660 (2016). Barragan, P., Garitey, V., Mouneimne, K. & Rieu, R. Longitudinal compression behaviour of coronary stents: a bench-top comparative study. 19, 818819 (2018). Thromboresistance and functional healing in the COBRA PzF stent versus competitor DES: implications for dual anti-platelet therapy. 39, 213260 (2017). Eighty percent (80%) of the sirolimus is released during the first 30 days. cordis (band) - Wikipedia Explaining the company's decision, Cordis group chair and worldwide chair Seth Fischer stated, "Due to evolving market dynamics in the drug-eluting stent business, we see greater opportunities to benefit patients and grow our business in other areas of the cardiovascular-device market.". 10-year clinical outcome after randomization to treatment by sirolimus- or paclitaxel-eluting coronary stents. 8600 Rockville Pike CAS Google Scholar. Poulsen, C. B. et al. In experimental animal models, abluminally coated biodegradable-polymer DES and polymer-free DES allow earlier healing and faster return of endothelial barrier function than durable-polymer DES, owing to curtailed duration of drug residence in the arterial wall. JACC Cardiovasc. Pathology of second-generation everolimus-eluting stents versus first-generation sirolimus- and paclitaxel-eluting stents in humans. Cardiovasc. Mit Ihrer Anmeldung erklren Sie sich damit einverstanden, Inhalte von uns zu erhalten. Nakazawa, G. et al. The company will also consolidate its Research and Development project teams in Fremont, California. Am. Durable polymers, particularly fluoropolymers, are protective against thrombogenicity in the acute phase after stent implantation. Coll. Navarese, E. P. et al. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. researched data for the article. Byrne, R. A., Stone, G. W., Ormiston, J. Circulation 103, 28162821 (2001). These statements are based on current expectations of future events. By signing up you agree to receive content from us. Summary of risk estimates for secondary outcomes with early aspirin discontinuation vs dual antiplatelet therapy after coronary stenting. "Due to evolving market dynamics in the drug-eluting stent (DES) business, we see greater opportunities to benefit patients and grow our business in other areas of the cardiovascular device market," said Seth Fischer, Company Group Chair and Worldwide Chairman, Cordis Corporation. 29, 10411049 (2018). , , , , , , Environmental, Social and Governance (ESG), HVAC (Heating, Ventilation and Air-Conditioning), Machine Tools, Metalworking and Metallurgy, Aboriginal, First Nations & Native American. 6, e005386 (2017). 16, 13681372 (2010). J. Cardiol. The sirolimus-eluting Cypher stent (Cordis Corp, a Johnson and Johnson Company, Miami, FL, USA) was approved by FDA in April 2003. . EuroIntervention 14, 11291135 (2018). Eur. Cardiol. Continue reading. Cision Distribution 888-776-0942 Aloke V. Finn. Heart Assoc. Eur. CORDIS Announces Results of Ten-Year CYPHER(R) Sirolimus-Eluting Virmani, R. et al. Palmerini, T. et al. have received institutional research support from 480 Biomedical, 4C Medical, 4Tech, Abbott, Accumedical, Amgen, Bard, Biosensors, Boston Scientific, Cardiac Implants, Celonova, Claret Medical, Concept Medical, Cook, CSI, DuNing, Edwards LifeSciences, Emboline, Endotronix, Envision Scientific, Gateway, Leducq Foundation Grant (R01 HL141425), Lifetech, Limflo, MedAlliance, Medtronic, Mercator, Merill, Microport Medical, Microvention, Mitraalign, Mitra assist, NAMSA, Nanova, Neovasc, NIPRO, Novogate, Occulotech, OrbusNeich Medical, Phenox, Profusa, Protembis, Qool, Recor, Senseonics, Shockwave, Sinomed, Spectranetics, Surmodics, Symic, Vesper, W.L. What is it? 4, 13101317 (2011). J. Urban, P. et al. 4 The stent's manufacturer, Cordis Corporation, and the US Food and Drug . Implantation of drug-eluting stents (DES) is the main treatment strategy for patients with coronary artery disease. Cordis Unveils CoCr Coronary Stent. Mehilli, J. et al. Welcome to Cordis Simultaneous intravascular ultrasound usage overcomes misinterpretation when evaluating lipid-rich plaques with optical frequency domain imaging ex vivo study. En vous inscrivant la newsletter, vous consentez la rception de contenus de notre part. Cardiol. Cision Distribution 888-776-0942 Safety and efficacy of everolimus- versus sirolimus-eluting stents: 5-year results from SORT OUT IV. Am. Do Not Sell or Share My Personal InformationLimit the Use of My Sensitive Personal InformationCookie Settings. The CYPHER(R) stent is the most studied drug-eluting stent in the world, it has a proven safety profile out to 10 years and has been used in nearly 4 million patients worldwide. Interv. Med. Circ. The company intends to close two manufacturing facilities: Cashel, Ireland, where the NEVO Stent was to be produced, and San German, Puerto Rico, the manufacturing site for the CYPHER Stent products. Garg, S., Bourantas, C. & Serruys, P. W. New concepts in the design of drug-eluting coronary stents. Stent coating integrity of durable and biodegradable coated drug eluting stents. Krucoff, M. W. LEADERS FREE II: evaluation of a polymer-free coronary drug-eluting stent in high bleeding-risk patients with one-month dual antiplatelet therapy [abstract]. Natl Acad. The sirolimus helps limit the overgrowth of normal cells while the artery heals. The CYPHER(R) stent has a unique closed-cell design that allows the medicine to be distributed more evenly across the treated area and that helps to keep the arteries open and the blood flowing to the heart, reducing the chance of re-intervention in the treated area. "Cypher was really the Coke of the sodas, the name brand synonymous with drug-eluting stents," Kandzari said. Ormiston, J. Cardiol. 1994; 331: . Sirolimus-FKBP12.6 impairs endothelial barrier function through protein kinase C-alpha activation and disruption of the p120-vascular endothelial cadherin interaction. A.V.F. 165, 415420 (2013). The Nevo, however, has faced a number of hurdles--the NEVO II study was suspended last year due problems with the stent delivery catheter, and according to Kandzari, NEVO III has never gotten off the ground. Cardiol. The CYPHER(R) stent has consistently proven to control late loss across all vessel sizes and across a broad patient population, even in the most complex types of patients such as patients with diabetes and acute myocardial infarction. Interv. S.T., A.S., M.K., A.C., S.K., L.G., H.M., E.H., K.H.P., R.F., R.V. Surg. 26 deaths in total were observed in this series; 16 of these patients had cardiogenic shock (7 late presenters), and three patients expired after discharge due to possible acute stent thrombosis. Heart J. Together, these businesses share the common goal of providing lasting and minimally invasive treatments to improve and extend the lives of patients suffering from cardiovascular disease. Comparison of the endothelial coverage in everolimus and zotarolimus-eluting stents in normal, atherosclerotic, and bifurcation rabbit iliac arteries. 41, 14281444 (2013). Coronary Artery Stents - StatPearls - NCBI Bookshelf This site is governed solely by applicable U.S. laws and governmental regulations. EuroIntervention https://doi.org/10.4244/EIJ-D-18-00740 (2018). Buddy wires were used in 36 cases. The company will continue to focus on cardiovascular care through its Biosense Webster and Cordis businesses: Biosense Webster will continue to build and expand on its global leadership position in the $2.5 billion electrophysiology (EP) market, as an innovative provider of advanced cardiac diagnostic, therapeutic, and mapping tools. Comparison of biologic effect and particulate embolization after femoral artery treatment with three drug-coated balloons in healthy swine model. Restenosis, stent thrombosis, and bleeding complications: navigating between Scylla and Charybdis. If you log out, you will be required to enter your username and password the next time you visit. Commenting is limited to medical professionals. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (, European Heart Journal. Copyright 2023. Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial. Plot of hazard ratio for stent thrombosis (A), stroke (B), and major bleeding (C) associated with early aspirin discontinuation (experimental therapy) vs dual antiplatelet therapy (control therapy). Comparison of in vivo longitudinal strength and conformability following stent implantation in rabbit iliac artery. Am. ", Heartwire from Medscape2011 Medscape, LLC. Heart J. JACC Cardiovasc. Coronary angioplasty and stenting in acute coronary syndromes with very Cardiol. 69, 616624 (2017). Watanabe, M. et al. Fujii, K. et al. 3, 11901198 (2010). Scientific Reports Cardiol. J. Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent: should we be cautious? At the same time, long-term data show some competitive DES offerings will adequately meet patients' medical needs once Cordis exits the market. J. General Information CORDIS RETURN POLICY (excluding the CYPHER Sirolimus-eluting Coronary Stents) Return Authorization Return Goods Condition Prior to return of any Cordis Corporation product for credit consideration, approval for the return needs to be requested by phoning Johnson & Johnson Health Care Systems Sales Support Center at 1-800-327-7714 option 2, or by logging on to www . Correspondence to To safely perform angioplasties in acute coronary syndromes with very low contrast volume using Cordis diagnostic catheters and thereby improve the cardiovascular and renal outcomes. 48, 193202 (2006). reviewed and edited the manuscript before submission. Through the company's innovation, research and development, Cordis works with interventional cardiologists, interventional radiologists and vascular surgeons worldwide to treat millions of patients who suffer from vascular disease. Rogers, C. & Edelman, E. R. Endovascular stent design dictates experimental restenosis and thrombosis. Acute in-hospital stent thrombosis was seen in 6 cases, which were managed with balloon dilatations and stents. Covid19 was positive in 16 cases by RT PCR. Unlicensed competition from products that infringe Cordis patents, both owned and licensed, has eroded CYPHER Stent pricing, sales and market share, and has dampened the prospects for NEVO Stent commercialization. J. Invasive Cardiol. Int. When typing in this field, a list of search results will appear and be automatically updated as you type. Angioplasty is often combined with the placement of a small wire . Circulation 113, 273279 (2006). Coronary angioplasty (AN-jee-o-plas-tee), also called percutaneous coronary intervention, is a procedure used to open clogged heart arteries. (This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. J. Wilson, G. J. et al. Interv. Through the company's innovation, research and development, Cordis partners with interventional cardiologists worldwide to treat millions of patients who suffer from vascular disease. And while he admits the newer stents have the advantage of being much more deliverable, he maintains there are still circumstances in which having the Cypher on hand would be a welcome option. Am. Copies of this Form 10-K, as well as subsequent filings, are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. PubMed J. Bridgewater, NJ (June 15, 2011) -- Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2. Int. Overall, the company expects to reduce 900 - 1,000 positions, subject to any consultation procedures on these plans in countries where required. More recently, ex vivo study has been conducted on several of the more commonly used coronary drug-eluting stents, including 2005 to 2006 versions of the Cypher (Johnson & Johnson/Cordis), Taxus Express (Boston Scientific), Taxus Liberte (Boston Scientific), and Endeavor (Medtronic) stents. Coll. (TM) Plus Stent, the third version of a sirolimus-eluting coronary stent, received CE Mark in 2006 and is currently . Drug-Eluting Stents | Circulation - AHA/ASA Journals Ninety one patients had creatinine more than 2mg/dl before the angioplasty procedures. Cordis Corporation Release: CYPHER(R) Sirolimus-eluting Coronary Stent Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Interv. Gupta, M. L. Jr., Bode, C. J., Georg, G. I. In a separate news release today, Cordis' parent company, Johnson & Johnson, announced the financial implications of Cordis' restructuring plans. Am. 441, 665679 (2013). In 76% of cases, iodixanol was used. Houghton, P. J. Everolimus. In a separate news release today, Cordis parent company, Johnson & Johnson, announced the financial implications of Cordis restructuring plans. Bridgewater, NJ (June 15, 2011) -- Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. Int. Circulation 123, 14001409 (2011). The company intends to close two manufacturing facilities: Cashel, Ireland, where the NEVO Stent was to be produced, and San German, Puerto Rico, the manufacturing site for the CYPHER Stent products. Google Scholar. Interv. Palmerini, T. et al. Sho Torii,Hiroyuki Jinnouchi,Atsushi Sakamoto,Matthew Kutyna,Anne Cornelissen,Salome Kuntz,Liang Guo,Hiroyoshi Mori,Emanuel Harari,Ka Hyun Paek,Raquel Fernandez,Maria E. Romero,Frank D. Kolodgie,Renu Virmani&Aloke V. Finn, School of Medicine, University of Maryland, Baltimore, MD, USA, Diljon Chahal,Anuj Gupta&Aloke V. Finn, You can also search for this author in Nakano, M. et al. Drug-eluting stents (DES) were successfully introduced into clinical practice for percutaneous coronary interventions (PCI) as a response to high rate of restenosis associated with bare-metal stents (BMS). Eppihimer, M. J. et al. Mechanical properties and performances of contemporary drug-eluting stent: focus on the metallic backbone. 67, 751762 (2016). Circulation 91, 29953001 (1995). 92, 253259 (2018). Acute thrombogenicity of fluoropolymer-coated versus biodegradable and polymer free stents. . 26, 6469 (2014). The .gov means its official. Nat. Meredith, I. T. et al. 6, 370377 (2013). Biol. R.V. Lancet 392, 940949 (2018). This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Heart J. For more information about Cordis please visit: www.cordis.com (this site is intended for US visitors only). Thank you for visiting nature.com. "Due to evolving market dynamics in the drug-eluting stent (DES) business, we see greater opportunities to benefit patients and grow our business in other areas of the cardiovascular device market," said Seth Fischer, Company Group Chair and Worldwide Chairman, Cordis Corporation. Acute thrombogenicity of a durable polymer everolimus-eluting stent relative to contemporary drug-eluting stents with biodegradable polymer coatings assessed ex vivo in a swine shunt model. Never before have cardiologists been faced with so many choices of stent, each with its own unique design. 38, 22172224 (2018). [2] The ensemble's first album, Here On Out, recorded at Q Division Studios in Boston, MA later that year, was produced by Tom Durack and Grimes and . Vasc. Together, these businesses share the common goal of providing lasting and minimally invasive treatments to improve and extend the lives of patients suffering from cardiovascular disease. Habib, A. et al. As the leader in EP navigation systems and ablation therapy, Biosense Webster has technology that includes the largest installed base of cardiac mapping navigation systems worldwide in leading hospitals and teaching institutions and a robust product pipeline. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Cordis Corporation and/or Johnson & Johnson. Article has received honoraria from Abbott Vascular, Biosensors, Boston Scientific, Celonova, Cook Medical, Cordis, CSI, Lutonix Bard, Medtronic, OrbusNeich Medical, CeloNova, SINO Medical Technology, ReCore, Spectranetics, Terumo Corporation and W. L. Gore. The company also recently received FDA approval for the EXOSEAL Vascular Closure Device. Nat. Bioengineering 5, E71 (2018). is a consultant for Amgen, Abbott Vascular, Boston Scientific, Celonova, Cook Medical, Lutonix Bard and Sinomed. Hypersensitivity reaction in the US Food and Drug Administration-approved second-generation drug-eluting stents: histopathological assessment with ex vivo optical coherence tomography. 25, 383390 (2013). Finn, A. V. et al. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Cordis will expand its portfolio of vascular solutions for endovascular and cardiology procedures, a $12 billion market. Vranckx, P. et al. Am. By PBR Staff Writer. The other authors declare no competing interests. Dynamics in the DES market have changed considerably in recent years and continue to evolve in areas such as demand, pricing and reimbursement, and regulatory requirements for breakthrough new technologies. Cardinal Health 12 May, 2016, 09:00 ET DUBLIN, Ohio, May 12, 2016 /PRNewswire/ -- Cardinal Health today announced that it has entered into a distribution agreement with Biosensors that enables. EuroIntervention 9, 14541462 (2014). Coronary responses and differential mechanisms of late stent thrombosis attributed to first-generation sirolimus- and paclitaxel-eluting stents. Sirolimus-eluting coronary stents: a review - PMC - National Center for Neoatherosclerosis: overview of histopathologic findings and implications for intravascular imaging assessment. Stent Restenosis Study Investigators. Optical coherence tomography findings in patients with coronary stent thrombosis: a report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort). Rationale and design of the EVOLVE Short DAPT Study to assess 3-month dual antiplatelet therapy in subjects at high risk for bleeding undergoing percutaneous coronary intervention. Careers, Unable to load your collection due to an error. Cardiol. Circulation 131, 322324 (2015). BRIDGEWATER, N.J., June 15, 2011 /PRNewswire-FirstCall/ -- Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. Comparison of vascular response between durable and biodegradable polymer-based drug-eluting stents in a porcine coronary artery model. The follow-up procedure was broadcast live during the 2009 meeting of the Latin America Society of Interventional Cardiology (SOLACI, Rio de Janeiro - Brazil). 76% of the cases had diabetes. The company will also stop the manufacture of CYPHER and CYPHER SELECT Plus Sirolimus-Eluting Coronary Stents by the end of 2011. Mridha, N. et al. Catheter. These businesses will also evaluate opportunities in areas where significant need and promising technologies exist. Med. A randomized comparison of coronary-stent lacement and balloon angioplasty in the treatment of coronary artery disease. Cordis Announces Discontinuation Of Nevo Sirolimus-Eluting Coronary Stent, Company To Focus On Areas Of Significant Patient Need In Cardiovascular Disease. Coll. Product catalog - Cordis - PDF Catalogs | Technical Documentation Kandzari told heartwire he found out about the news "from Wall Street," while Simon said he received a call from Cordis executive Campbell Rogers early Wednesday. Torii, S. et al. Imaging 8, 451460 (2015). Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis. Lancet 379, 13931402 (2012). ", Campbell Rogers, M.D., Chief Scientific Officer and Global Head R&D at Cordis, said, "We continue to be gratified by the outstanding performance of CYPHER(R) compared with other drug-eluting stents. Yazdani, S. K. et al. The company will continue to focus on cardiovascular care through its Biosense Webster and Cordis businesses: Biosense Webster will continue to build and expand on its global leadership position in the $2.5 billion electrophysiology (EP) market, as an innovative provider of advanced cardiac diagnostic, therapeutic, and mapping tools. Angioplasty and stenting can be performed safely in patients with acute coronary syndromes using Cordis diagnostic catheters and a very low volume of contrast with improved clinical outcomes. Eur. Imaging 9, 163172 (2016). BRIDGEWATER, N.J., Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. Please select your country to continue. IVUS was used in only two patients. Colombo, A., Giannini, F. & Briguori, C. Should we still have bare-metal stents available in our catheterization laboratory? Pathophysiology of restenosis Stent-induced restenosis involves a complex interplay of biological events. Eur. In 2000, patients were enrolled in the RAVEL Trial, the first multi-center, randomized, double-blind, trial in history for drug-eluting stents. Nakazawa, G. et al. June 15, 2011 (Bridgewater, New Jersey) The first company to bring a drug-eluting stent (DES) to worldwide markets is not only dropping development of its novel reservoir-based DES design, it. Please see our Privacy Policy. Wilson, G. J. et al. Circ. 29, 483490 (2016). Am. Outcomes of Percutaneous Coronary Intervention for InStent Restenosis Subsequently, newer-generation DES were introduced with thinner struts, different scaffold designs (to improve deliverability while maintaining radial strength), different durable and biodegradable polymers and in some cases no polymer (to improve vascular biocompatibility) and new antiproliferative drug types and doses. Copy and send link X. Cordis, a Johnson & Johnson company, has launched a bare metal stent system Presillion Plus in Europe. Eur. The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents. Three, six, or twelve months of dual antiplatelet therapy after DES implantation in patients with or without acute coronary syndromes: an individual patient data pairwise and network meta-analysis of six randomized trials and 11 473 patients. When typing in this field, a list of search results will appear and be automatically updated as you type. Cypher was really the Coke of the sodas, the name brand synonymous with drug-eluting stents. Am. Drug-eluting coronary stents: insights from preclinical and pathology studies. Circulation 139, 325333 (2019). Van der Heiden, K. et al. Chichareon, P. et al. Cordis Corporation's CYPHER(R) Sirolimus-eluting Coronary Stent Am. 166, 755758 (2013). Clin. Because restenosis within the stented region of a heart artery is caused by tissue growth, some stents (called drug-eluting stents) have medication on them to inhibit or prevent this tissue growth. Ann. But the company has been so secretive about whether there has been any progress made.". This website also contains material copyrighted by 3rd parties. The impact of in-stent neoatherosclerosis on long-term clinical outcomes: an observational study from the Kobe University Hospital optical coherence tomography registry. Torii, S. et al. These businesses generated 2010 sales of $1.9 billion*, representing an operational growth rate of 8 percent versus the prior year. Arterioscler. Expert Rev. Cordis Announces Discontinuation of NEVO Sirolimus-Eluting Coronary Stent An official website of the United States government. Circulation 136, 13041314 (2017). BRIDGEWATER, N.J.,Cordis Corporation, a worldwide leader in the development and manufacture of interventional vascular technology, today announced it will no longer pursue the development of the NEVO Sirolimus-Eluting Coronary Stent in order to focus on other cardiovascular therapies where significant patient need exists. ", CYPHER(R) sirolimus-eluting coronary stent in detail. Impact of stent surface on thrombogenicity and vascular healing: a comparative analysis of metallic and polymeric surfaces. The company intends to close two manufacturing facilities: Cashel, Ireland, where the NEVO Stent was to be produced, and San German, Puerto Rico, the manufacturing site for the CYPHER Stent products. Characteristics of earlier versus delayed presentation of very late drug-eluting stent thrombosis: an optical coherence tomographic study. 7, e011245 (2018). Coronary stenting (Cordis) without anticoagulation - PubMed The trial was conducted in 15 centers in Europe and 4 in Latin American and presented by Dr Marie Claude Morice at the Annual Congress of the European Society of Cardiology in Stockholm on 4th September 2001. We conclude by discussing how these design characteristics might affect the potential for shortening the minimum duration of dual antiplatelet therapy needed after coronary intervention. Before Get the most important science stories of the day, free in your inbox. 21 June 2022, Nature Communications A key trial showing the efficacy of CYPHER(R) stent found that up to 5 years after receiving the stent, the risk of restenosis of the artery is reduced by 60 - 70% compared to an uncoated stent. Angioplasty uses a tiny balloon catheter that is inserted in a blocked blood vessel to help widen it and improve blood flow to the heart. A regular follow-up of the patients was performed 30 days after the procedure. J. Cardiol. 373, 20382047 (2015). The company will continue to focus on cardiovascular care through its Biosense Webster and Cordis businesses: Biosense Webster will continue to build and expand on its global leadership position in the $2.5 billion electrophysiology (EP) market, as an innovative provider of advanced cardiac diagnostic, therapeutic, and mapping tools. 5, e003803 (2016). Sci. Circ. 205, 110117 (2018). CYPHER's(R) body of clinical evidence is completely unmatched by any other drug-eluting stent. 79, 26412647 (2015). EuroIntervention 11, e1619e1626 (2016). 1,2 Pooled analyses from randomized studies with paclitaxel-eluting and sirolimus-eluting stents showed similar mortality and myocardial infarction (MI) rates, but less repeat .

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